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KMID : 1137820060270060409
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의공학회지
2006 Volume.27 No. 6 p.409 ~ p.417
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Total Activity Estimation of Hippocampal Slice Using Multi-Electrode Array
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Lee Jeong-Chan
Kim Ji-Eun
Cho Chung-Yean
Son Min-Sook
Park Kyung-Mo
Park Ji-Ho
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Abstract
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Research on neural circuit is a difficult area due to complexity and inaccessibility. Due to recent developments, the research using multi-electrode array of cells or tissues has become an important research area. However, there are some difficulties to decode the submerged meaning from huge and complex neural data. Moreover, it needs a harmonic collaboration between informatics and bioscience. In this paper, we have developed a custom-designed signal processing technique for multi-electrode array measured neural responses induced by electrical stimuli to the hippocampal tissue slices of the rat brain. The raw data from hippocampal slice using the multi-electrode array system were saved in a computer. Then we estimated characteristic points in each channel and calculated the total activity. To estimate the points, we used the Polynomial Fitting Approximation Method. Using the calculated total activity, we could provide the histogram or pseudo-image matrix to help interpretation of results.
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KEYWORD
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multi-electrode array, brain slice, hippocampus, total activity, polynomial fitting
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